If you’ve been searching for ways to treat erectile dysfunction (ED), you’ve likely come across various options—pills, gels, devices, and even injections. But for most men, ED tablets remain the most effective and accessible solution. At Simply Meds Direct, we understand how overwhelming it can be to choose the right treatment, especially if it’s your first time. This guide breaks down how oral ED medication works, what to expect, and why it often performs better than alternatives like erectile dysfunction cream.

What Causes Erectile Dysfunction?

Before diving into how ED medication works, it helps to understand the problem it’s designed to solve. ED is the inability to achieve or maintain an erection firm enough for sexual activity. It’s more common than you might think—affecting millions of men in the UK alone.

While ED can be caused by a range of physical and psychological factors, the root issue is often reduced blood flow to the penis. This can happen due to stress, anxiety, underlying health conditions like diabetes or heart disease, smoking, obesity, or even certain medications.

What Are PDE5 Inhibitors?

Most prescription ED tablets fall under a group of medicines known as PDE5 inhibitors. This includes well-known names like sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Spedra).

PDE5 inhibitors work by relaxing the blood vessels in the penis, allowing blood to flow more easily when a man is sexually stimulated. These medications don’t automatically trigger an erection—you still need sexual arousal—but they make it physically possible for one to occur and be sustained.

How Do ED Tablets Work in the Body?

When a man is aroused, the body releases a chemical called nitric oxide. This sets off a chain reaction that leads to the production of cyclic guanosine monophosphate (cGMP), a molecule that helps relax the smooth muscle tissue in the penis, allowing for increased blood flow.

Here’s where PDE5 inhibitors come in: they block the enzyme (PDE5) that breaks down cGMP. This allows cGMP to remain active for longer, supporting a firmer, longer-lasting erection.

Each medication in this class varies slightly:

Sildenafil usually starts working within 30–60 minutes and lasts around 4–6 hours.

Tadalafil can start working in 30 minutes and may last up to 36 hours.

Vardenafil is effective within 30–60 minutes, with effects lasting 4–5 hours.

Avanafil has a faster onset (15–30 minutes) with a shorter duration.

Get in touch with us to learn more about our full range of ED treatment options.

Why Are Tablets More Effective Than Creams or Gels?

There are topical alternatives available—like erectile dysfunction creams and gels—but they often fall short in terms of effectiveness and convenience.

Erectile dysfunction cream typically works by increasing local blood flow when applied to the penis. While this might seem like a straightforward solution, there are several drawbacks:

Inconsistent results: Creams may not be absorbed evenly or effectively across different skin types.

Timing: They often need to be applied shortly before intercourse, which can interrupt the moment.

Skin sensitivity: Some men report irritation or burning sensations.

Partner transfer: There’s a risk of the cream transferring to a sexual partner, which could lead to unwanted side effects.

In contrast, tablets work internally, producing systemic effects that support natural erectile function without the mess or timing issues. With oral medication, you can plan ahead and feel more confident going into an intimate situation.

What to Expect When Taking ED Tablets

If it’s your first time using a PDE5 inhibitor, here are a few things to keep in mind:

Take as directed: Most tablets are taken with water on an empty stomach for best results.

Allow time: Give the medication time to work—typically 30 to 60 minutes before sexual activity.

Stay relaxed: You still need sexual stimulation for the medication to take effect.

Watch interactions: Avoid heavy alcohol, grapefruit juice, or nitrate-containing medications, as they can interfere with the drug’s action.

Side effects are usually mild and temporary. These may include headaches, flushing, nasal congestion, or indigestion. If you experience chest pain, dizziness, or a prolonged erection, seek medical attention immediately.

Your ED Treatment Starts Here

At Simply Meds Direct, we offer a discreet and secure service to help you find the right treatment for erectile dysfunction. Whether you’re considering a PDE5 inhibitor for the first time or want to understand your options beyond erectile dysfunction cream, our online consultations make it easy to get expert guidance and quick delivery—all from the comfort of home.

Don’t let ED affect your confidence or relationships. With the right treatment and support, things can get better—quickly and safely.

This blog was written on behalf of Simply Meds Direct by Pharmacy Mentor.