Erectile dysfunction (ED) affects many men at different stages of life, and choosing the right treatment can feel overwhelming. For most, the journey starts with tablets like sildenafil (Viagra) or tadalafil (Cialis). However, when tablets aren’t effective—or if side effects become an issue—some men turn to erection injections as a highly reliable alternative.

At Simply Meds Direct, we help men explore both options confidentially, so they can regain control of their sexual health. In this blog, we’ll compare how oral ED medications and erection injections work, their success rates, side effects, and how to decide which treatment might be right for you.

What Are Erection Injections?

Erection injections involve directly injecting a medication (usually alprostadil) into the base or side of the penis. The most well-known brand is Caverject, and it works by widening blood vessels to improve blood flow—resulting in an erection, typically within 5 to 20 minutes.

Unlike tablets, which require sexual stimulation to take effect, erection injections are mechanically reliable. Once injected correctly, an erection usually occurs whether or not there’s mental arousal.

How Do ED Tablets Work?

Tablets like sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Spedra) work by relaxing blood vessels and improving blood flow to the penis in response to sexual stimulation. They belong to a class of medications called PDE5 inhibitors.

These are often the first-line treatment for ED and are easy to take, discreet, and effective for most men. Each tablet has its own timing, duration, and strength:

Sildenafil: Takes effect in 30–60 minutes, lasts up to 4–6 hours

Tadalafil: Takes 30 minutes, but lasts up to 36 hours

Vardenafil: Similar to sildenafil, with a slightly quicker onset

Avanafil: Fast-acting, sometimes within 15 minutes

Comparing Success Rates

ED Tablets:

Tablets have a high success rate for mild to moderate ED. Around 70–80% of men respond well to PDE5 inhibitors, particularly when taken correctly and combined with proper arousal.

However, for men with severe ED, nerve damage, diabetes, or those taking certain medications (such as nitrates), tablets may not be effective.

Erection Injections:

Erection injections are often used when tablets have failed. The success rate is extremely high—up to 85–90%, even in men with more complex health conditions.

Because the injection delivers medication directly into the penile tissue, it bypasses the digestive system and works regardless of nerve function or arousal.

Ease of Use and Convenience

Tablets:

Pills are clearly more convenient. They can be taken discreetly before sex and require no special equipment. Most men feel more comfortable with oral medication, and there’s less psychological barrier to use.

Erection Injections:

Learning to use an erection injection correctly can take time. While it’s straightforward with training, it does involve handling a needle, timing the injection properly, and rotating injection sites to avoid tissue damage. This method requires more commitment, but some men find it empowering once they get used to it.

Side Effects and Risks

Tablets:

Common side effects include headaches, flushing, nasal congestion, and occasional digestive discomfort. Some men may experience visual disturbances or muscle aches, particularly with tadalafil.

Erection Injections:

The most common side effect is mild pain or bruising at the injection site. Rare but serious risks include prolonged erection (priapism) or fibrosis (scarring) with long-term use. However, these risks are low when used correctly under guidance.

Discretion and Timing

ED tablets are easier to fit into a spontaneous lifestyle. With tadalafil, for example, many men enjoy a 36-hour window of effectiveness, giving them greater flexibility.

Erection injections are more planned and can feel clinical at first. That said, many men find them to be liberating once oral medications stop working, restoring confidence and function with reliable results.

Which Should You Choose?

If you’re just starting to address erectile dysfunction, oral medication is usually the best place to begin. It’s simple, safe, and effective for the majority of men. However, if tablets haven’t worked—or if you’re looking for a more guaranteed result—erection injections could offer the reliable solution you need.

At Simply Meds Direct, we offer both options. Our online consultations are discreet and reviewed by UK-based prescribers who will help you choose what’s best for your needs.

Ready to Take the Next Step?

If you’ve tried tablets without success, or you’re looking to explore other options in a supportive, confidential environment, Simply Meds Direct is here to help. We offer a range of erectile dysfunction treatments, including oral medication and erection injection options like Caverject.

Our online consultation service is discreet, reviewed by UK-based prescribers, and designed to match you with the right treatment based on your individual needs. Contact us to take control of your sexual health and confidence with trusted advice, fast delivery, and tailored care from a team that understands.

This blog was written on behalf of Simply Meds Direct by Pharmacy Mentor.